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 Life extension of mice
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Dude
SFN Die Hard

USA
6891 Posts

Posted - 05/05/2005 :  22:46:52  Show Profile Send Dude a Private Message
... by altering them to overproduce antioxidant enzymes.

http://www.sciencemag.org/cgi/content/abstract/1106653v1?etoc

You'll need a subscription to view the entire text I think, but here is a blurb from the first paragraph. Good stuff.

quote:
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the peroxisome (PCAT), nucleus (NCAT), or mitochondrion (MCAT). Median and maximum lifespans were maximally increased (average 5 months, and 5.5 months, respectively) in MCAT animals. Cardiac pathology and cataract development were delayed, oxidative damage was reduced, H2O2 production and H2O2-induced aconitase inactivation were attenuated, and the development of mitochondrial deletions was reduced. These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals.




Interesting implications, to say the least.


Ignorance is preferable to error; and he is less remote from the truth who believes nothing, than he who believes what is wrong.
-- Thomas Jefferson

"god :: the last refuge of a man with no answers and no argument." - G. Carlin

Hope, n.
The handmaiden of desperation; the opiate of despair; the illegible signpost on the road to perdition. ~~ da filth
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